pentobarbital will lessen the extent or effect of montelukast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. minimal/importance Unknown. pentobarbital will lower the extent or influence of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/watch carefully. sturdy or moderate CYP3A4 inducers noticeably le… Read More